Publication of 2,000 Canine Genomes Provides Toolkit for Translational Research

An international research consortium has generated and analyzed 2,000 canine genomes. The resulting advanced genetics toolkit can now be used to answer complex biological questions, spanning dog domestication, genetic differences in breed morphology, behavior, and disease susceptibility, as well as the evolution and structure of the genome. The study, published August 15, 2023 in Genome Biology, describes the toolkit resource package and presents the first set of discoveries. The publication is the culmination of efforts from the Dog10K consortium; 48 scientists across 25 institutions, contributing samples and resources to the immense analytical effort. The open-access article is titled “Genome Sequencing of 2000 Canids by the Dog10K Consortium Advances the Understanding of Demography, Genome Function and Architecture.” “The goal was to produce a resource the global community could access, and which they could use to speed the translation of their own research, be that in the study of the shared ancestors of dogs and wolves, or the clinical treatment of cancers. All these avenues are exciting, and all can benefit from the Dog10K catalogue,” says Uppsala University research scientist, Jennifer Meadows, PhD, co-lead author of the study.
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