World-First Discovery May Enable an Effective Long-Term Lupus Treatment; Expert Terms Breakthrough “Profound” and a “Game-Changer”

Australian researchers have worked out how to fix a defect that causes lupus, and hope their world-first discovery will offer effective long-term treatment. Published February, 6, 2024 in Nature Communications, the Monash University-led study found a way to reprogram the defective cells of lupus patients with protective molecules from healthy people. The open-access article is titled “Smith-Specific Regulatory T Cells Halt the Progression of Lupus Nephritis.” Using human cells, the new treatment restores the protective side of the immune system that prevents autoimmunity, which is when the immune system attacks its own cells. The findings relate to the autoimmune disease lupus, a debilitating disease with no cure and limited treatments.

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