A cellular murder mystery in fruit flies explains a human immunodeficiency, with applications for immunotherapy.
Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency. Now the discovery shows promise for enhancing an up-and-coming cancer treatment. “This paper takes us from very fundamental cell biology in a fly, to explaining a human disease and harnessing that knowledge for a cancer therapy,” said UC Santa Barbara’s Denise Montell, PhD. “Each one of those steps feels like a major discovery, but here they are, all in one paper.” Researchers in Montell’s lab published their findings in PNAS on December 18, 2023, and are now investigating the mechanisms and implications. The open-access article is titled “Hyperactive Rac Stimulates Cannibalism of Living Target Cells and Enhances CAR-M-Mediated Cancer Cell Killing.”