On September 22, 2022, it was announced that University of Texas (UT) Southwestern sleep researcher Masashi Yanagisawa, MD, PhD, has shared the Breakthrough Prize in Life Sciences for his discovery of the cause of narcolepsy in work that has led to new treatments for this condition that results in dangerous daytime sleepiness. Dr. Yanagisawa was honored along with Emmanuel Mignot, MD, PhD, of Stanford University, who made the same discovery independently. The Breakthrough Prizes announced for 2023 are the world’s most lucrative science awards. The other awardees in life science include Clifford Brangwynne and Anthony Hyman, for discovering a new mechanism of cellular organization; and Demis Hassabis, and John Jumper for developing AlphaFold, which accurately predicts the structure of proteins.