Unraveling the Role of Glioblastoma Stem Cells and Exosomes in Temozolomide (TMZ) Resistance

by Manisha Kashyap, PhD

Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults, poses significant challenges in treatment due to its resistance to standard therapies, such as temozolomide (TMZ) chemotherapy. In a ground-breaking study published May 6 in Cell Death & Disease, researchers delve into the intricate mechanisms underlying GBM drug resistance, focusing on the pivotal role of glioblastoma stem cells (GSCs) and their communication via exosomes. The open-access article is titled “Glioblastoma Stem Cells Deliver ABCB4 Transcribed by ATF3 Via Exosomes Conferring Glioblastoma Resistance to Temozolomide.” The study unveils a novel pathway wherein GSCs confer resistance to TMZ by transferring the ATP-binding cassette transporter ABCB4 to differentiated glioma cells (DGCs) through exosomes. Through a comprehensive series of in vitro and in vivo experiments, the researchers elucidate the molecular intricacies of this process, shedding light on potential targets for therapeutic intervention in GBM.

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