Uncharacterized Transcript Confers Cachexic Phenotype on Cancer Cells

A new research paper was published in Oncotarget's Volume 14 on July 20, 2023, entitled, “The Uncharacterized Transcript KIAA0930 Confers a Cachexic Phenotype on Cancer Cells.” Patients with cancer cachexia have a poor prognosis and impaired quality of life. Numerous studies using preclinical models have shown that inflammatory cytokines play an important role in the development of cancer cachexia; however, no clinical trial targeting cytokines has been successful. Therefore, it is essential to identify molecular mechanisms to develop anti-cachexia therapies. In this new study, researchers Takahiro Yamakawa, Guoxiang Zhang, Liza Bengrine Najjar, Chun Li, and Keiichi Itakura from the Beckman Research Institute of City of Hope identified the uncharacterized transcript KIAA0930 as a candidate cachexic factor based on analyses of microarray datasets and an in vitro muscle atrophy assay.  “We here report the initial characterization of KIAA0930,” the authors wrote.

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