The Importance of a Disturbed Lipid Metabolism in Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth (CMT) disease, a group of heritable disorders that affect the peripheral nerves, is marked by specific genetic changes. Research by the team of Prof. Ludo Van Den Bosch (VIB-KU Leuven) now reveals the effects of one such genetic cause. They found that the duplication of the gene PMP22 causes problems in the cell membrane of Schwann cells that provide the insulating cover for nerves. The results appeared May 14, 2024 in Brain. The open-access article is titled PMP22 Duplication Dysregulates Lipid Homeostasis and Plasma Membrane Organization in Developing Human Schwann Cells.”
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