Taking Closer Look at Pulmonary Fibrosis Genetics

Study is the first to map variations in gene regulation at the cell-type level throughout the lung

Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease’s biology? A team of scientists led by researchers from the Translational Genomics Research Institute (TGen), part of the City of Hope, together with investigators at St. Vincent’s Institute of Medical Research and Vanderbilt University Medical Center, now have a better answer for this question when it comes to pulmonary fibrosis (PF), an incurable respiratory disease. Their study, published March 28,2024 in Nature Genetics, is the first to look at these variations at the cell type level across all cells within a solid tissue—in this case, the lung. The open-access article is titled “Cell-Type-Specific and Disease-Associated Expression Quantitative Trait Loci in the Human Lung.”

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