Study Offers Potential Strategy to Improve T Cell Therapy in Solid Tumors; Simultaneous Knockout of Two Inflammatory Regulators Boosts T Cell Expansion in Models

A new approach that delivers a “one-two punch” to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania. The findings, published on March 15, 2023 in PNAS, showed that targeting two regulators that control gene functions related to inflammation led to at least 10 times greater T cell expansion in models, resulting in increased antitumor immune activity and durability. The open-access article is titled “Combined Disruption of T Cell Inflammatory Regulators Regnase-1 and Roquin-1 Enhances Antitumor Activity of Engineered Human T Cells.”