Study: Movement Disorder ALS and Cognitive Disorder FTLD Show Strong Molecular Overlaps

Single-cell gene expression patterns in the brain, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment.

Manolis Kellis, PhD

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, manifest in very different ways. In addition, they are known to primarily affect very different regions of the brain. However, doctors and scientists have noted several similarities over the years, and a new study appearing March 22, 2024 in Cell reveals that the diseases have remarkable overlaps at the cellular and molecular levels, revealing potential targets that could yield therapies applicable to both disorders. The article is titled “Single-Cell Dissection of the Human Motor and Prefrontal Cortices in ALS and FTLD.”

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