Study Finds Unexpected Protective Properties of Pain; Work in Mice Illuminates How Pain Neurons Shield Gut from Damage; Harvard Study Published in Cell

Pain has been long recognized as one of evolution’s most reliable tools to detect the presence of harm and signal that something is wrong — an alert system that tells us to pause and pay attention to our bodies. But what if pain is more than just a mere alarm bell? What if pain is in itself a form of protection? A new study led by researchers at Harvard Medical School (HMS) suggests that may well be the case in mice. The research, published on October 14, 2022 in Cell, shows that pain neurons in the mouse gut regulate the presence of protective mucus under normal conditions and stimulate intestinal cells to release more mucus during states of inflammation. The article is titled “Nociceptor Neurons Direct Goblet Cells Via a CGRP-RAMP1 Axis to Drive Mucus Production and Gut Barrier Protection.”