Study Demonstrates Use of ACE Technology for Direct Isolation of Exosomes

On July 12, 2017, Biological Dynamics announced the publication of data in ACS Nano demonstrating that the company's proprietary lab-on-a-chip ExoVerita™ system can simplify and streamline the process for isolation and recovery of exosomes. The company is using this technology to develop a portfolio of minimally-invasive diagnostic tests to provide faster answers to critical clinical questions in high-burden diseases, such as cancer, traumatic brain injury, and infectious diseases. The ACS Nano article, published online on July 3, 2017, is titled “Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma.” Exosomes are cell-derived, extracellular vesicles that enable communication between cells. They are secreted from most cell types and released in bodily fluids such as urine, blood plasma, and saliva. Due to their stability and ability to transport information about their origin and the state of their parental cells, exosomes are believed to have great potential to power the next generation of liquid biopsies and cancer biomarkers. "Current exosome isolation methods are generally expensive, complex, and cumbersome, which could limit large-scale diagnostic applications," said Michael Heller, PhD, principal investigator on the paper and scientific advisory board member of Biological Dynamics. "This study describes a relatively simple, rapid, and non-destructive method for the isolation of exosomes, that preserves their valuable biomarker information for direct analysis.
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