Study Casts Doubt on Theory That Retired NFL Football Players Suffer Chronic Traumatic Encephalopathy (CTE)

The media have widely reported that a debilitating neurological condition called chronic traumatic encephalopathy (CTE) is a well-established disease in retired athletes who played football and other contact sports. But a study by a Loyola University Medical Center neuropsychologist has found little evidence that CTE actually exists. "There has not yet been one controlled epidemiological study looking at the risk of late-life cognitive impairment in any collision sport, including boxing, American football, or other sports involving repetitive head trauma," Christopher Randolph, Ph.D., reports in an open-access article in the January-February 2014 peer-reviewed journal Current Sports Medicine Reports. The author declares no conflict of interest and has no financial disclosures. CTE is said to be the cause of behavioral symptoms such as anger, aggression and suicidality, and cognitive symptoms such as impaired learning and memory problems. CTE is thought to be linked to concussions and characterized by the build-up of abnormal substances in the brain called tau proteins. A 2005 study, co-authored by Dr. Randolph, reported that rates of mild cognitive impairment among retired National Football League (NFL) players seemed to be higher than that of the general population, but Dr. Randolph noted there were no controls in this study, and results may have been subject to reporting biasb A more recent study of retired NFL players found that rates of Alzheimer's disease and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) were higher than that of the general population. But this may be due to the fact that the NFL players had lower overall mortality rates from heart disease and other causes. Because they lived longer, the players naturally would be more likely to get age-related diseases such as Alzheimer's disease.
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