Stem Cell-Derived Exosomes May Treat Underlying Causes of Polycystic Ovary Syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a pervasive endocrine disorder that affects millions of women globally, impacting their hormonal balance, fertility, and overall well-being. It is notoriously difficult to treat, with widely varying symptoms and mysterious, complex underlying causes. Researchers at the University of Chicago (UChicago) recently unveiled a potential new PCOS treatment that may improve multiple PCOS symptoms by regulating body systems and reducing inflammation. Recently published results demonstrate the promise of this novel therapeutic approach that uses mesenchymal stem cell-derived extracellular vesicles (EVs), also known as exosomes: tiny, free-floating packages of molecules released by stem cells, as well as by all cells that have been studied for such release. “Current PCOS treatments merely address the symptoms, and the most common treatments--oral contraceptives--do not address patients’ struggles with infertility,” said Hang-Soo Park, PhD, staff scientist at UChicago and the study’s first author. “Our approach represents a paradigm shift from symptom management to treating the underlying causes. We hope this will prove more effective in the long term and allow patients to have children if they wish to do so.”

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