High-sensitivity assays for cardiac troponin T can quickly and safely rule out myocardial infarction (MI) in patients presenting to emergency departments (ED) with possible emergency acute coronary syndrome. A single troponin T concentration below the limit of detection in combination with a non-ischemic electrocardiogram (EKG) means that MI is unlikely and patients can be safely discharged. The findings of a collaborative meta-analysis study were published on April 18, 2017 the in Annals of Internal Medicine. The article is titled “Rapid Rule-Out of Acute Myocardial Infarction with a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-Analysis.” Only 10 to 20 percent of patients who present to EDs with suspected cardiac-related chest pain are diagnosed with acute MI. High-sensitivity assays for cardiac troponin T have been used to rapidly rule out acute MI, but studies advocating this approach have several limitations. If findings can be validated across multiple studies that are free of these limitations, then this approach could enable safe discharge of many more patients than is achieved in current practice. Researchers at Christchurch Hospital in Christchurch, New Zealand reviewed published data to test the utility of a single high-sensitivity cardiac troponin T measurement combined with an ECG to safely identify patients at low risk for MI on presentation to the ED. To address limitations of previous studies, the review included 11 clinically and geographically diverse cohorts. The data showed that in most, but not all settings, patients investigated for acute coronary syndrome with the cardiac troponin T assay had very low risk for acute MI or for major adverse cardiac events within 30 days.
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