Simple, Exosome-Based Blood Test May Allow Earlier Detection of Breast Cancer Progression or Relapse; If Proven Successful, Such Testing Could “Revolutionize” Patient Care

In a release issued on September 9, 2016, it was announced that researchers at The University of Western Australia (UWA) are working on a quick, simple, and less invasive blood-based test (using exosomes) that can detect breast cancer progression or relapse much earlier than current methods such as mammogram, MRI, or biopsy. Dr. Katie Meehan (photo) from UWA’s School of Pathology and Laboratory Medicine is leading the project, which is currently recruiting participants with breast cancer. Dr. Meehan said through testing before, during, and after treatment, the researchers intend to develop a new test that would improve cancer progression monitoring and health outcomes. “Women in rural and remote areas would benefit significantly from the new diagnostic blood test to monitor for low levels of residual or recurrent disease,” Dr. Meehan said. “Currently it’s costly, time-consuming, and physically draining for these women to travel to Perth for regular treatment, whereas the new test could be done by a routine pathology lab anywhere. It will enable cancer patients to find out at the earliest possible time whether their cancer had returned. Our research examines cancer ‘exosomes’ which are parts of the cancer shed into the body fluids that can drive the spread and aggressiveness of cancer. These exosomes, or biomarkers of disease, can be detected during routine blood tests and, because early studies show that exosome levels increase with more aggressive cancers, our research will monitor exosome levels in patients’ blood during treatment. We hope to show that when exosomes become undetectable in the blood, this indicates the cancer is gone or if exosomes remain in the blood, this may identify a cancer at risk of returning.” Dr.
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