
A July 26, 2024 Nature News article by Smrity Mallapaty reports on the seventh person “cured” of HIV after a stem-cell transplant and why scientists are excited. The patient is only the second to have received stem cells not resistant to HIV by virtue of mutations in both copies of the CCR5 gene. The donor cells for this patient had a mutation in just one of the two CCR5 genes so were likely to express some CCR5. CCR5 is a receptor on cells that HIV latches onto. The case sends a clear message that finding a cure for HIV is “not all about CCR5,” says infectious-disease physician Sharon Lewin, who heads The Peter Doherty Institute for Infection and Immunity in Melbourne, Australia. The case was presented at the AIDS 2024: 25th International AIDS Conference in Munich, Germany.
