Secrets of the Naked Mole-Rat: New Study Reveals How Their Unique Metabolism Protects Them from Heart Attacks

Long-lived naked mole-rat

This unusual, subterranean mammal with extreme longevity shows genetic adaptations to low oxygen environments which could offer opportunities for advancing other areas of physiological and medical research in humans, including the development of novel therapeutic approaches. New research from Queen Mary University of London led by Dr. Dunja Aksentijevic in the Faculty of Medicine and Dentistry has revealed that that the genome of the naked mole-rat contains specific adaptations that allow them to survive in low-oxygen, and even no-oxygen environments in their natural habitat. The findings also show the mammals’ distinct cardiometabolic profile helps to avoid damage to their hearts caused by cardiovascular events.

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