Secreted Factors from Mesenchymal Stromal Cells, Including Factors in Extracellular Vesicles, May Be Promising Treatment for Infections with Methicillin-Resistant Staphylococcus aureus (MSRA) “Super-Bug”

A study published online on September 16, 2021 in STEM CELLS Translational Medicine (SCTM), by researchers at the Baker Institute for Animal Health, part of Cornell University’s College of Veterinary Medicine, Ithaca, New York, details, in a relevant ex vivo model, how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus (MSRA) viability and stimulated the surrounding skin cells to build up a defense against the bacterial invader. The open-access article is titled “Mesenchymal Stromal Cell Secreted CCL2 Promotes Antibacterial Defense Mechanisms Through Increased Antimicrobial Peptide Expression in Keratinocytes."
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