Scientists Slow Aging by Engineering Longevity in Cells; Researchers Build Biosynthetic Genetic “Clock” to Extend Lifespan by 82% in Yeast Cells

Human lifespan is related to the aging of our individual cells. Three years ago, a group of University of California San Diego (UCSD) researchers deciphered essential mechanisms behind the aging process. After identifying two distinct directions that cells follow during aging, the researchers genetically manipulated these processes to extend the lifespan of cells. As described April 28, 2023 in Science, they have now extended this research using synthetic biology to engineer a solution that keeps cells from reaching their normal levels of deterioration associated with aging. Cells, including those of yeast, plants, animals and humans, all contain gene regulatory circuits that are responsible for many physiological functions, including aging. The Science article is titled “Engineering Longevity—Design of a Synthetic Gene Oscillator to Slow Cellular Aging.”

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