Scientists Reverse Age-Related Memory Loss in Mice; Approach May Prove Useful in Humans

Scientists at the University of Cambridge and University of Leeds have successfully reversed age-related memory loss in mice and say their discovery could lead to the development of treatments to prevent memory loss in people as they age. In a study published on July 16, 2021 in Molecular Psychiatry, the team shows that changes in the extracellular matrix of the brain - 'scaffolding' around nerve cells--lead to loss of memory with aging, but that it is possible to reverse these using genetic treatments. The open-access article is titled “Chondroitin 6-Sulphate Is Required for Neuroplasticity and Memory in Ageing.”