Scientists Identify Novel Molecular Biomarkers in Cells That Spread Triple-Negative Breast Cancer; May Serve As Therapeutic Targets

Studying a deadly type of breast cancer called triple-negative, Johns Hopkins Medicine scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors. The research, using mouse models and human tissues, could pave the way for developing new treatments that target such molecular variations. A report on the findings was published August 3, 2022 in Science Translational Medicine. The article is titled “Triple-Negative Breast Cancer Metastasis Involves Complex Epithelial-Mesenchymal Transition Dynamics and Requires Vimentin.” The subject served as the cover story of the August 3, 2022 online issue of Science Translational Medicine.