Scientists Achieve A to G Base Conversion in Mitochondria, the Final Missing Piece of the Puzzle in Gene-Editing Technology; “It Is Expected That TALED Will Usher in a New Era of Genome Engineering”

Researchers from the Center for Genome Engineering within Korea’s Institute for Basic Science have developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED. TALEDs are base editors capable of performing A-to-G base conversion in mitochondria. This discovery was a culmination of a decades-long journey to cure human genetic diseases, and TALED can be considered to be the final missing piece of the puzzle in gene-editing technology.