Same Target, Different Effects

The outer membrane of Gram-negative bacteria is a target for antibiotics.

E. coli

For more than a hundred years, bacteria have been classified into Gram-positive and Gram-negative pathogens according to their staining patterns. Gram-negative bacteria present a significant challenge, because they are enveloped by a second membrane that prevents many antibiotics from penetrating. “On the other hand, the enzymes that produce this outer membrane are unique and are therefore promising targets for specific antibiotics against this group of bacteria,” explains Professor Franz Narberhaus, PhD, holder of the Chair of Microbial Biology, Ruhr University (Germany) and study leader.

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