Rutgers Researchers Shed Light on Role of Key Fat-Regulating Enzyme in Human Health; Findings May Hold Clues to Obesity, Diabetes, Cancer, And Other Diseases

had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists at Rutgers University-New Brunswick have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation, and other ills. Their findings were published online on July 3, 2017 in the Journal of Biological Chemistry. "The goal of our lab is to understand how we can tweak and control this enzyme," said Dr. George M. Carman, Board of Governors Professor in the Department of Food Science in the School of Environmental and Biological Sciences. "For years, we have been trying to find out how to fine-tune the enzyme's activity so it's not too active, and creating too much fat, but it's active enough to keep the body healthy." The JBC article is titled “Yeast PAH1-Encoded Phosphatidate Phosphatase Controls The Expression of CHO1-Encoded Phosphatidylserine Synthase for Membrane Phospholipid Synthesis.”
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