RNA Silencing of Mutated NRAS Gene May Be Potential Giant Mole Reversal Therapy in Rare Condition (CMN); Results Termed “Very Exciting”

Researchers at the Francis Crick Institute, UCL Great Ormond Street Institute for Child Health, and Great Ormond Street Hospital for Children (GOSH) have designed a new genetic therapy that could alleviate debilitating giant moles in a rare skin condition. In the future, the treatment could potentially be used to reverse the giant moles, and therefore reduce the risk of affected children and adults from developing cancer. It could also potentially reverse other more common types of at-risk moles as an alternative to surgery. Small skin moles are common in the population, but in congenital melanocytic naevus syndrome (CMN), children are born with up to 80% of their body covered in big, painful or itchy moles, caused by mutations acquired in the womb. These moles can sometimes develop into a severe type of cancer called melanoma.

Login Or Register To Read Full Story