RNA Modification Is Responsible for the Disruption of Mitochondrial Protein Synthesis in Alzheimer’s Disease

Methylation of mRNA disturbs the production of ND5, a subunit of complex I of the respiratory chain / Impairment of the brain's energy supply

A team of researchers at Johannes Gutenberg University Mainz (JGU) has identified a mechanism that causes mitochondrial dysfunction in Alzheimer’s patients resulting in a reduction of the supply of energy to the brain. "This effect is attributable to an RNA modification that has not previously been reported," said Professor Kristina Friedland of the Institute of Pharmaceutical and Biomedical Sciences at JGU. She supervised the related study in collaboration with her colleague Professor Mark Helm. Their results contribute to a better understanding of the pathophysiology of Alzheimer's disease. Also involved in the research were groups at the Mainz University Medical Center, the Institute of Molecular Biology (IMB), Université de Lorraine, and the Medical University of Vienna. The corresponding paper has been published in Molecular Psychiatry.
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