RNA Markers in Saliva May Reveal Deadly Diseases Early Enough to Treat Them, UCLA Scientists Analyze 165 Million Genetic Sequences from Saliva; Fluid Found to Be Surprisingly Rich Source of microRNA, piRNA, and circRNA

UCLA research could lead to a simple saliva test capable of diagnosing — at an early stage — diabetes and cancer, and perhaps neurological disorders and autoimmune diseases. The study, the most comprehensive analysis ever conducted of RNA molecules in human saliva, demonstrates that saliva contains many of the same disease-revealing molecules that are contained in blood. It was published online today by the peer-reviewed journal Clinical Chemistry and was published Clinical Chemistry’s January 2015 special print issue, “Molecular Diagnostics: A Revolution in Progress.” “If we can define the boundaries of molecular targets in saliva, then we can ask what the constituents in saliva are that can mark someone who has pre-diabetes or the early stages of oral cancer or pancreatic cancer — and we can utilize this knowledge for personalized medicine,” said Dr. David Wong, a senior author of the research and UCLA’s Felix and Mildred Yip Endowed Professor in Dentistry. Dr. Wong said the test also holds promise for diagnosing Type 2 diabetes, gastric cancer, and other diseases. “If you don’t look in saliva, you may miss important indicators of disease,” Dr. Wong said. “There seems to be treasure in saliva, which will surprise people.” RNA, widely known as a cellular messenger that makes proteins and carries out DNA’s instructions to other parts of the cell, is now understood to perform sophisticated chemical reactions and is believed to perform an extraordinary number of other functions, at least some of which are unknown. Dr. Wong’s research over the past decade has focused on identifying biomarkers in saliva.
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