Revelations About Mechanisms of Two Key Proteins Which Maintain Asymmetric Distribution of Cholesterol Within Cell Membrane Could Help Understanding and Treatment of Diseases Linked to Cholesterol Imbalance; Article Published in JBC

Cholesterol is an essential component of the membrane surrounding every human bcell, despite its poor reputation as a health concern when its blood levels are too high. The key to health is having the right amount of cholesterol in the right places. Maintaining appropriate levels is known as cholesterol homeostasis. Researchers at the Institute for Integrated Cell-Material Science (iCeMS) at Kyoto University in Japan have gained new insights into how cells achieve cholesterol homeostasis within the cell membrane. The findings were published on December 9, 2022 in Journal of Biological Chemistry (JBC). The open-access article is titled “ABCA1 and Cholesterol Transfer Protein Aster-A Promote an Asymmetric Cholesterol Distribution in the Plasma Membrane.”