Researchers Use Pioneering New Method to Unlock Brain’s Noradrenaline System—Work Represents “a Milestone in Our Efforts to Understand the Functions of Human Brain Circuits” Expert Comments

An international team of researchers has provided valuable insights into the brain’s noradrenaline (NA) system, which has been a longtime target for medications to treat attention-deficit/hyperactivity disorder, depression, and anxiety. Equally important beyond the findings is the ground-breaking methodology that the researchers developed to record real-time chemical activity from standard clinical electrodes that are routinely implanted for epilepsy monitoring. Published online in the journal Current Biology on Monday (Oct. 23), the research not only provides new insights into the brain’s chemistry, which could have implications for a wide array of medical conditions, it also highlights a remarkable new capacity to acquire data from the living human brain. The open-access article is titled “Noradrenaline Tracks Emotional Modulation of Attention in Human Amygdala.”

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