Proven to protect against a wide array of diseases, exercise may be the most powerful anti-aging intervention known to science. However, while physical activity can improve health during aging, its beneficial effects inevitably decline. The cellular mechanisms underlying the relationship among exercise, fitness, and aging remain poorly understood. In a paper published on January 3, 2023 in PNAS, researchers at the Joslin Diabetes Center investigated the role of one cellular mechanism in improving physical fitness by exercise training and identified one anti-aging intervention that delayed the declines that occur with aging in a model organism. Together, the scientists’ findings open the door to new strategies for promoting muscle function during aging. The article is titled “Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics.”
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