Researchers Identify Key Regulators Underlying Regeneration in Drosophila

Control fly wing (top) and Brat-reduced fly wing (bottom). (Credit: Authors of the paper)
Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail. However, this regenerative process must be tightly regulated by the body to ensure proper tissue organization and to prevent abnormal growths, such as cancer. Yet, the precise mechanisms underlying this regulation are not well known. In a recent study published in PLOS Genetics, researchers at the University of Illinois Urbana-Champaign (UIUC) have identified an RNA-regulator called Brat as a key player in restraining tissue regeneration through its modulation of downstream growth factors. The open-access article was published on December 21, 2023 and is titled “Regenerative Growth Is Constrained by brain tumor to Ensure Proper Patterning in Drosophila.”
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