Researchers Engineer Bacteria That Can Detect Tumor DNA in Gut; Advanced Biosensor Leverages Gene Swapping to Identify Colon Cancer; “A Living Bacterium That Can Detect DNA in the Gut Is a Tremendous Opportunity to Act As a Sentinel to Seek and Destroy Gastrointestinal, and Many Other, Cancers,” Expert Comments

Pushing into a new chapter of technologically advanced biological sensors, scientists from the University of California San Diego and colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism. Their innovation, which detected cancer in the colons of mice, could pave the way to new biosensors capable of identifying various infections, cancers and other diseases. The advancement was published August 9, 2023, in the journal Science. Bacteria previously have been designed to carry out various diagnostic and therapeutic functions, but lacked the ability to identify specific DNA sequences and mutations outside of cells. The new “Cellular Assay for Targeted CRISPR-Discriminated Horizontal Gene Transfer,” or “CATCH,” was designed to do just that.

Login Or Register To Read Full Story