Researchers Discover Potential Target for Gastric Cancers Associated with Epstein-Barr Virus

Now, scientists at The Wistar Institute and colleagues have discovered a potential target for gastric cancers associated with Epstein-Barr virus; study results were published in the journal mBio. In the paper, Wistar’s Tempera lab investigates the epigenetic characteristics of gastric cancer associated with the Epstein-Barr virus: EBVaGC. In evaluating EBVaGC’s epigenetics — the series of biological signals associated with the genome that determines whether a given gene is expressed — the Tempera lab highlights a target that could advance as a future treatment for this type of cancer. The August 22, 2023 open-access mBio article is titled “Decitabine Disrupts EBV Genomic Epiallele DNA Methylation Patterns Around CTCF Binding Sites to Increase Chromatin Accessibility and Lytic Transcription Characteristics of Gastric Cancer Associated with the Epstein-Barr Virus: EBVaGC.”