Pre-cancer is a lesion containing abnormal cells that have not invaded neighboring tissues even though epidemiological, experimental, or clinical evidence for an increased risk of developing cancer exists. As such, pre-cancer is an alluring clinical option. “We want to stop cancer before it develops,” said Catriona H. M. Jamieson, MD, PhD, UCSD Moores Cancer Center, who opened the AACR’s first-ever plenary session dedicated to the science of pre-cancer on Saturday, April 9. The session, Pre-Cancer Discovery Science, can be viewed on the virtual platform by registered meeting participants through July 13, 2022. Registration can be done here. Over 19,000 scientists and physicians registered for this premier cancer conference, with ~80% (~15,200) attending in person and ~20% (~3,800) attending virtually. The AACR has over 50,000 members worldwide.