Researchers at Houston Methodist Find Difference in Pancreatic Cancer Cells, Offering New Hope for Immunotherapy Effectiveness

Diagram of pancreas

A new study has found that pancreatic cancer cells are different based on their location in the pancreas, providing new information about tumors that could lead to better targeted treatments. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer, and the diagnosis has dramatically increased over the last decade. It is currently the seventh leading cause of cancer deaths in men and women globally and projected to be the third leading cause of cancer-related deaths world-wide by 2030. This increase is due to several factors such as an increase in obesity and diabetes. Houston Methodist’s section chief of gastrointestinal medical oncology, Dr. Maen Abdelrahim, served as first and concept-generating author for the article titled, “Comparative Molecular Profiling of Pancreatic Ductal Adenocarcinoma of the Head Versus Body and Tail, published April 6, 2024 in NPJ Precision Oncology, an online journal in the Nature family of publications. The research team discovered that the anatomical location of the pancreatic tumor is a contributing factor for the outcomes of systematic therapy interventions.

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