Research Reveals FKBP5 Gene Variant Affects Chronic Pain After Traumatic Injury Because It Alters Ability of the Gene to Be Regulated by a MicroRNA

The gene FKBP5 is a critical regulator of the stress response and affects how we respond to environmental stimuli. Previous studies have shown that certain variants of this gene play a role in the development of neuropsychiatric disorders such as posttraumatic stress disorder, depression, suicide risk, and aggressive behavior. But in 2013, University of North Carolina (UNC) School of Medicine researchers were first to show an association between genetic variants in FKBP5 and posttraumatic chronic pain. In particular, the study found that people with a variant or minor/risk allele on chromosome 6 known as rs3800373 are likely to experience more pain after exposure to trauma (such as sexual assault or motor vehicle collision) compared to people who don't have this variant. Now, a new study by the same research group, published in the Journal of Neuroscience, has confirmed this association in a cohort of more than 1,500 people of both European American and African American descent who experienced motor vehicle collision trauma. Sarah Linnstaedt (photo), PhD, Assistant Professor of Anesthesiology and an investigator in the Institute for Trauma Recovery, is the study's lead author. The article is titled “A Functional riboSNitch in the 3′UTR of FKBP5 Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Posttraumatic Pain.” "In our current study, we showed that the reason this variant affects chronic pain outcomes is because it alters the ability of FKBP5 to be regulated by a microRNA called miR-320a," Dr, Linnstaedt said. MicroRNAs play an important role in the regulation of gene expression, primarily by degrading or repressing the translation of messenger RNA (mRNA). "In individuals with the minor/risk allele, the microRNA does not bind well to FKBP5," she said.
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