The following is a note from Tal Behar, President of the Precision Medicine World Conference (PMWC) which will be taking place in person in Silicon Valley, California January 25-27, 2023: Real-world evidence (RWE)-based approaches will increasingly influence clinical decision-making as real-world data (RWD) analysis methods advance, along with expanding acquisition, aggregation, and harmonization of RWD from traditional and novel sources. Growth of real-world datasets will elevate statistical power and generalizability, and ultimately is expected to enhance disease prevention and management across clinical domains and populations. However, this progress will require that the precision medicine community ensures that RWD are unbiased and drawn from diverse populations. Indeed, realizing the promise of precision medicine will depend upon empowering RWD to identify and address health disparities.