Protein from Liver May Cause Alzheimer’s Disease (AD) in the Brain; Peripherally Produced Amyloid Causes Neurodegeneration; Results Suggest Dietary Approach and/or Targeted Drugs May Be Helpful in Preventing/Treating AD

Amyloid protein made in the liver can cause neurodegeneration in the brain, according to a new study in the open-access journal PLOS Biology, by lead investigator John Mamo, PhD, of Curtin University in Bentley, Australia, and colleagues. Because the protein is thought to be a key contributor to development of Alzheimer’s disease (AD), the results suggest that the liver may play an important role in the onset or progression of the disease. The open-access article was published online on September 14, 2021 and is titled “Synthesis of Human Amyloid Restricted to Liver Results in an Alzheimer Disease–Like Neurodegenerative Phenotype.”