On Friday, January 27, the three-day Precision Medicine World Conference 2023 (PMWC 2023) (Jan 25-27) “Celebrating 14 Years of Precision Medicine Innovation” concluded in Santa Clara, California, the heart of Silicon Valley, with day-long sessions on six different topic tracks. These included Pharmacogenomics, AI & Data Sciences in Drug Discovery & Clinical Research, Population Scale Omics, Imaging Applications; and two showcase sessions—one on AI & Data Sciences, Emerging Therapeutics, and Genomic & Microbial Profiling, and the other on Clinical Diagnostics and Clinical & Research Tools. The day also included presentation of four PMWC Pioneer Awards and two PMWC Luminary Awards. Pioneer Awards were presented to David Bently, PhD, Dan M. Roden, MD, Lea T. Grinberg, MD, PhD, and Daniela Ushizima, PhD . Luminary Awards were presented to Gad Getz, PhD, and Kelly Caudle, Pharm.D, PhD. The meeting ended with a powerful futuristic presentation by biotech legend and visionary Leroy Hood, MD, PhD.