Poweful Anti-Microtubule Drugs for Cancer Treatment Made Light-Sensitive and Switched On and Off with Single-Cell Precision; Common Systemic Side-Effects Eliminated; Broader Applications Envisioned

A new technique that uses light to activate chemotherapy drugs in specific cells shows promise as a way to improve the effectiveness of cancer therapies while preventing severe side effects, according to a study published online on July 9, 2015 in Cell. Tha article is titled “Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.” The so-called “photopharmacology” approach could be used to treat a broad range of tumors with unprecedented precision simply by making existing cancer drugs sensitive to light--an approach that requires less time and effort compared with traditional drug discovery programs. "We hope that our compounds will one day be used in medicine to deliver a killer blow to many types of localized cancer tumors, without producing side effects, thus improving on standards of care and also providing chemotherapy options for currently untreatable tumors," says co-senior author Dr. Oliver Thorn-Seshold of Ludwig-Maximilians-Universität München in Germany. Some of the most successful and widely used chemotherapeutic drugs are inhibitors that interfere with the function of microtubules--components of the cell's skeleton that play a key role in cell proliferation, migration, and survival. But because these drugs do not specifically target cancer cells, they also interfere with the function of normal cells and cause severe side effects, such as heart and nerve damage. As a result, microtubule inhibitors are often limited to relatively low doses that do not provide the best therapeutic benefit. To overcome this challenge, Dr. Thorn-Seshold and his collaborators developed a method for optically controlling microtubule inhibitor drugs currently in clinical trials, with high spatial precision.
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