PolyQ-Binding Protein 5 (PQBP5) Forms Scaffold in Nucleolus Under Normal and Stressed Conditions, Is an Essential Protein Needed to Maintain Structure of Nucleolus; and Is Bound by Polyglutamine Disease Proteins

PQBP5 is an essential structural component of the nucleolus. This 3D image of a single nucleolus shows the interactions among three nucleolar proteins: PQBP5 (green) forms a lattice-like meshwork ball that anchors assembly of fibrillarin (red) and nucleolin (blue). (Credit: Department of Neuropathology, TMDU).
Everyone has that one friend who’s the life of the party, bringing people together and keeping everyone connected. Now, researchers from Japan find that an unusually structured protein plays a similar role in bringing a diverse group of proteins together and keeping them connected and functional. In a study published on January 4, 2023 in Nature Communications, researchers from Tokyo Medical and Dental University (TMDU) have revealed that an intrinsically disordered protein (IDP) is crucial for the stability of an organelle called the nucleolus. The open-access article is titled “PQBP5/NOL10 Maintains and Anchors the Nucleolus Under Physiological and Osmotic Stress Conditions.”
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