Plenary Address on Immuno Cell-Cell Interactions Highlights Friday Session of International Society for Extracellular Vesicles (ISEV 2016) Annual Meeting in Rotterdam

The plenary address of Friday’s session of the International Society for Extracellular Vesicles annual meeting (ISEV 2016) in Rotterdam was delivered by the eminent immunologist and cell biologist Francisco Sanchez-Madrid, PhD, and was titled “Immune Cell-Cell Communication: Mechanisms of MicroRNA and Protein Sorting into Exosomes.” Dr. Sanchez-Madrid is Professor at the Universidad Autonoma de Madrid and Head of the Immunology Department at the La Princesa Hospital in Madrid. His address to the 800+ attendees in the filled amphitheater focused on two main topics: the exosome-driven transfer of genetic and mitochondria constituents through immune synapses [an immune synapse is the interface between an antigen-presenting cell or target cell and a lymphocyte such as an effector T-cell or natural killer cell; an immune synapse is also defined as a temporary membrane structure formed between immune cells in contact so as to effect communication], and the mechanisms of miRNA and protein sorting in exosomes. He first reported that there is unidirectional transfer of miRNA-loaded exosomes from activated T-cells at the immune synapse. He then showed evidence that mtDNA-binding proteins are contained in these exosomes, and, in fact, next-gen sequencing demonstrated that the entire mitochondrial genome is present in some of the exosomes. He then investigated whether mtDNA might trigger a signaling response in recipient cells. He noted that there is a potential role of T-cell exosomes as inhibitors of the innate immune response. Dr. Sanchez-Madrid then turned to a discussion of miRNA and protein sorting into exosomes.
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