Physics Meets Biology: Prion Protein Orchestrates Liquid-Liquid Phase Separation with Copper; New Study Reveals That Prion Protein and Copper Form Sticky Droplets Under Oxidative Stress, a Marker of Neurodegeneration

Prion protein
In a ground-breaking study published on November 3, 2023 in Science Advances, researchers from the Federal University of Rio de Janeiro (UFRJ) and the German Center for Neurodegenerative Diseases (DZNE-Berlin) shed light on the intricate dance between the prion protein and copper ions in the physiopathology of live cells. The research paves the way for potential treatments addressing copper-bound prion protein clusters to prevent abnormal solid formation and mitigate neurodegenerative outcomes. The open-access article is titled “Copper Drives Prion Protein Phase Separation and Modulates Aggregation.”
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