Pathogens Use Force to Breach Immune Defenses, Study Finds

Toxoplasma gondii
Similar to a burglar breaking a window to get into a house, Indiana University researchers have discovered a previously unknown process by which pathogens enter a cell with physical force, breaching the body's immune defenses that prevent infection. The work, published on November 30, 2023 in PNAS, introduces a potential game-changer in the fight against intracellular pathogens responsible for causing devastating infectious diseases, such as tuberculosis, malaria and chlamydia. These diseases are notoriously difficult to treat because the pathogens are protected inside host cells. The article is titled “Propulsive Cell Entry Diverts Pathogens from Immune Degradation by Remodeling the Phagocytic Synapse.”
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