Statistical genetic evidence supports the history-based theory that inbreeding may have played a role in the extinction of the Spanish Habsburg dynasty (1516-1700). This is the conclusion of research reported in an April 15 article in PLoS. The Spanish Habsburg dynasty was characterized by the frequent marrige of close relatives, in such a way that uncle-niece, first cousin, and other consanguineous unions were common. The dynasty ended with the childless death of the physically and mentally disabled Charles II at the age of 39. [PLoS article]
DICER1 Mutations Implicated in Rare Childhood Cancer
Mutations in the microRNA processing enzyme DICER1 appear to the cause of the inherited form of a rare, aggressive childhood cancer called pleuropulmonary blastoma (PPB). “PPB is the first malignancy found to be directly associated with inherited DICER1 mutations, making the cancer an important model for understanding how mutations and loss of DICER1 function lead …
Inhibition of the expression of a gene called NHERF-1 may be useful in the treatment of deadly brain cancers in the class glioblastoma multiforme (GBM), according to findings published by researchers at the Translational Genomics Research Institute (TGen) and Barrow Neurological Institute in the April issue of Neoplasia. “Our findings suggest a novel mechanism defining NHERF-1 as a ‘molecular switch’ that regulates the GBM tumor cell’s ability to migrate or divide,” said Dr. Kerri Kislin, the lead author of the study. The findings will be presented during the AACR annual meeting April 18-22. [