When U.S. President Joe Biden reignited his Cancer Moonshot initiative earlier this year with the ambitious goals of reducing the age-adjusted mortality of cancer by 50 percent over the next 25 years and improving the experience of living with and surviving cancer, it brought increased awareness to the cancer research community. In his Presidential Address on Sunday, April 10, outgoing AACR President David A. Tuveson, MD, PhD, AACR Fellow, elevated awareness of the unique challenges in the fight against pancreatic cancer and what it will take to achieve the targets of the Cancer Moonshot in this patient population. The American Association for Cancer Research (AACR) Annual Meeting, was held April 8-13 in New Orleans. Dr. Tuveson’s address, A Road Map to Defeat Pancreatic Cancer, and other meeting sessions can be viewed on the virtual platform by registered meeting participants through July 13, 2022. Registration can be done here. Over 19,000 scientists and physicians registered for this premier cancer conference, with ~80% (~15,200) attending in person and ~20% (~3,800) attending virtually. The AACR has over 50,000 members worldwide.