Olaparib Plus Ceralasertib May Benefit Pediatric Cancer Patients with DNA Repair-Deficient Tumors; Results Presented at AACR 2023

A combination of the PARP inhibitor olaparib (Lynparza) and the investigational ATR
inhibitor ceralasertib showed clinical benefit in pediatric patients with solid tumors exhibiting DNA replication stress and/or DNA repair deficiencies, according to results from the phase I portion of the phase I/II AcSé-ESMART trial presented at the American Association for Cancer Research (AACR) Annual Meeting 2023, held April 14-19 in Orlando, Florida.

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