Non-O Blood Groups Associated with Higher Risk of Heart Attack

Having a non-O blood group is associated with a higher risk of heart attack, according to research presented on April 30, 2017 at Heart Failure 2017 and the 4th World Congress on Acute Heart Failure in Paris, France. Lead author Tessa Kole, a Master's degree student at the University Medical Centre Groningen, the Netherlands, said: "It has been suggested that people with non-O blood groups (A, B, AB) are at higher risk for heart attacks and overall cardiovascular mortality, but this suggestion comes from case-control studies which have a low level of evidence. If this was confirmed it could have important implications for personalized medicine." The current study was a meta-analysis of prospective studies reporting on O and non-O blood groups, and incident cardiovascular events including myocardial infarction (heart attack), coronary artery disease, ischemic heart disease, heart failure, cardiovascular events, and cardiovascular mortality. The study included 1,362,569 subjects from 11 prospective cohorts, described in nine articles. There were a total of 23,154 cardiovascular events. The researchers analyzed the association between blood group and all coronary events, combined cardiovascular events, and fatal coronary events. The analysis of all coronary events included 771,113 people with a non-O blood group and 519,743 people with an O blood group, of whom 11,437(1.5%) and 7,220 (1.4%) suffered a coronary event, respectively. The odds ratio (OR) for all coronary events was significantly higher in carriers of a non-O blood group, at 1.09 (95% confidence interval [CI] of 1.06-1.13).
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