NIH Study Finds Neurotrophic Factor-a1 (Carboxypeptidase E) Prevents Memory Loss and Neurodegeneration in Mouse Model of Alzheimer’s Disease

Y. Ping Loh, PhD

Delivery of the gene for neurotrophic factor-α1 (NF-α1) directly into the hippocampus of the brain prevents neurodegeneration and memory loss in a mouse model of Alzheimer’s disease, according to a study led by NIH researchers. These preclinical findings on a potential therapeutic are among the first to show prevention of Alzheimer’s disease in an animal model. The results were published June 28, 2023 in Molecular Psychiatry. The open-access article is titled “Hippocampal Delivery of Neurotrophic Factor-α1/Carboxypeptidase E Gene Prevents Neurodegeneration, Amyloidosis, Memory Loss in Alzheimer’s Disease Male Mice.”

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